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Journal News Tuesday, January 06, 2009 \| Source: Circulation CACTUS: Provisional Stenting Equivalent to Crush in Bifurcations By Kiersten Feil In most bifurcations with significant stenosis in both the main and side branches, a strategy of stenting both branches with the crush technique does… Monday, January 05, 2009 \| Source: TCTMD TCTMD’s Top 10 Most Popular Stories for 2008 By Jason Kahn Providing a snap shot of the year in interventional cardiology, the most popular news stories that appeared on TCTMD in 2008 were dominated by stenting… Monday, January 05, 2009 \| Source: TCTMD Year In Review: Key Trials Highlight Role of PCI, DES in 2008 By Jason Kahn From head to head data comparing percutaneous coronary intervention (PCI) with coronary artery bypass grafting (CABG) to the rapid evolution of computed… Wednesday, December 31, 2008 \| Source: Lancet Another Group Links Key Genetic Variant to Poor CV Outcomes By Jason Kahn A group of French researchers has tied a key genetic allele associated with poor response to clopidogrel to worse clinical outcomes in young patients… Tuesday, December 30, 2008 \| Source: Canadian Medical Association Journal Short Term Gains with DES vs. BMS Even Out Over Long Term By Kim Dalton During the first year after implantation, patients receiving drug eluting stents (DES) show reduced rates of death and repeat revascularization compared… Monday, December 29, 2008 \| Source: Circulation: Cardiovascular Interventions Newer DES Less Harmful to Vessel Wall Function Than First Generation By Jason Kahn First generation drug eluting stents (DES) cause endothelial dysfunction in the implanted vessel, while newer DES behave similarly to bare metal stents… Tuesday, December 23, 2008 \| Source: NEJM Genetic Variants for Poor Clopidogrel Response Tied to Clinical Events By Jason Kahn Two studies investigating genetic variants linked with poor response to clopidogrel therapy have gone beyond assessing measures of platelet reactivity… Tuesday, December 23, 2008 \| Source: JACC SOS Published: Restenosis Rates Favor Taxus Over BMS for SVG Lesions By Kim Dalton In saphenous vein graft (SVG) lesions, Taxus significantly reduces rates of 12 month binary angiographic restenosis and target vessel failure (TVF) compared… Monday, December 22, 2008 \| Source: Circulation Cardiovascular Interventions Lupus Patients Suffer Far Worse Outcomes After PCI By Caitlin E. Cox Heart disease is a major complication among individuals with lupus, but little is known about how these patients fare after percutaneous coronary intervention… Monday, December 22, 2008 \| Source: Circulation: Cardiovascular Interventions One Stent Better Than Two for Left Main Bifurcations By Jason Kahn Findings from a large, observational study show that a “keep it simple” strategy of using a single drug eluting stent (DES) whenever possible instead… Friday, December 19, 2008 \| Source: TCTMD Q&A with Dr. Cindy Grines: Women and Interventional Cardiology By Kiersten Feil Spurred by the publication of a recent survey by the American College of Cardiology (ACC) showing that women face persistent barriers in cardiology (see… Friday, December 19, 2008 \| Source: Circulation: Cardiovascular Interventions Reassurance on Use of DES in STEMI By Kim Dalton Patients with an ST segment elevation myocardial infarction (STEMI) who receive primary percutaneous coronary intervention (PCI) with a drug eluting stent… Thursday, December 18, 2008 \| Source: JACC CTA Reliably Rules Out CAD, Specificity Still an Issue By Caitlin E. Cox In patients with stable or unstable angina, 64 slice computed tomographic angiography (CTA) effectively identifies the absence of significant coronary… Thursday, December 18, 2008 \| Source: Circulation: Cardiovascular Interventions Twenty Years of PCI: Stents Improve Outcomes, Except for Mortality By Jason Kahn As percutaneous coronary intervention (PCI) has evolved over the last 20 years, the procedure has included more urgent, complex cases while achieving… Wednesday, December 17, 2008 \| Source: NEJM TROICA Published: Early Thrombolysis Does Not Improve Cardiac Arrest Survival By Kim Dalton For patients in cardiac arrest who receive cardiopulmonary resuscitation (CPR) outside of the hospital, on the scene administration of tenecteplase—in… Wednesday, December 17, 2008 \| Source: JACC Women Still Underrepresented in Cardiology By Kiersten Feil The number of women doctors in cardiology almost doubled in the past 10 years, and both male and female cardiologists report a high level of job satisfaction,… Tuesday, December 16, 2008 \| Source: JACC: Cardiovascular Interventions Clopidogrel Within 30 Minutes Key for Bivalirudin’s Effectiveness By Caitlin E. Cox Bivalirudin is just as effective at preventing ischemic complications as heparin and a glycoprotein IIb IIIa inhibitor (GPI), provided that clopidogrel… Tuesday, December 16, 2008 \| Source: JACC: Cardiovascular Interventions PCI for STEMI Less Safe, Effective When Performed Off-Hours By Carson Benowitz-Fredericks Patients with ST segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PCI) are more likely to experience… Monday, December 15, 2008 \| Source: JACC: Cardiovascular Interventions DES Safe, Effective for Aggressive CAD in Heart Transplant Patients By Jason Kahn In patients with heart transplants who develop an aggressive form of coronary artery disease, drug eluting stents (DES) lower the rate of restenosis compared… Monday, December 15, 2008 \| Source: JACC: Cardiovascular Interventions Doubling Clopidogrel Maintenance Dose May Overcome Poor Response By Kim Dalton In patients who have undergone elective percutaneous coronary intervention (PCI), increasing the clopidogrel maintenance dose from 75 mg day to 150 mg… Monday, December 15, 2008 \| Source: JACC: Cardiovascular Interventions GP IIb-IIIa Inhibitors May Protect Poor Responders to Antiplatelet Drugs By Kiersten Feil Two studies published in the December 2008 edition of JACC Cardiovascular Interventions examine critical issues surrounding variability in antiplatelet… Monday, December 15, 2008 \| Source: JACC: Cardiovascular Interventions Studies Show Promise of Personalized Antiplatelet Therapy By Jason Kahn Two new studies take important steps toward personalizing clopidogrel therapy based on a patient’s pharmacogenetic profile. The first study demonstrates… Friday, December 12, 2008 \| Source: AHJ Sex Differences Still Exist for Women Receiving PCI for ACS By Caitlin E. Cox Despite efforts to improve practice, numerous gender differences persist between women and men who undergo percutaneous coronary intervention (PCI) for… Friday, December 12, 2008 \| Source: AHJ Study Calls Attention to Cancer Risk for Cath Lab Workers By Kim Dalton For most cath lab professionals, the extra risk of cancer from radiation exposure is acceptably low. However, longtime workers who receive significant… Thursday, December 11, 2008 \| Source: Circulation Does More Angiography Lead to Too Much Intervention? By Kiersten Feil While a strong, linear relationship exists between rates of coronary angiography and percutaneous coronary intervention (PCI), the same does not hold… Thursday, December 11, 2008 \| Source: AJC Elderly Women Face Higher Risk of Contrast Nephropathy By Jason Kahn Women aged 65 and older have a higher risk of contrast induced acute kidney injury following cardiac catheterization than their male counterparts, according… Wednesday, December 10, 2008 \| Source: Journal of Vascular Surgery Elderly More Likely to Receive Carotid Stents—Leading to More Strokes By Kim Dalton Octogenarians with carotid disease are no more likely than younger patients to suffer a stroke following stenting. But because these elderly patients… Wednesday, December 10, 2008 \| Source: Journal of Vascular Surgery Family History Doubles AAA Risk, Regardless of Sex By Caitlin E. Cox The risk of developing an abdominal aortic aneurysm (AAA) is nearly double for first degree relatives of patients who have been diagnosed with the condition… Tuesday, December 09, 2008 \| Source: European Society of Cardiology CT Complementary to Invasive Angiography, Not a Replacement, Says ESC By Kiersten Feil Despite media reports to the contrary, CT angiography (CTA) is not likely to replace invasive angiography but will instead complement it, according to… Tuesday, December 09, 2008 \| Source: Annals of Internal Medicine Women with Severe Regurgitation Have Less Surgery, Worse Survival By Carson Benowitz-Fredericks Among patients with mitral valve prolapse, sex is associated with differences in disease morphology, treatment, and long term mortality, according to… view all journal news Conference News Friday, November 21, 2008 \| Source: AHA: Scientific Sessions 2008 Higher Emergency PCI Volume Equals Lower Mortality in Community Hospitals By Caitlin E. Cox Community hospitals performing a higher volume of primary percutaneous coronary intervention (PCI) without on site cardiac surgery backup have lower in… Thursday, November 13, 2008 \| Source: AHA: Scientific Sessions 2008 No Relationship Between PFO, Migraine in Case-Control Study By Debra Beck NEW ORLEANS—No association exists between migraine headaches and the presence of patent foramen ovale (PFO), according to results from a large case control… Thursday, November 13, 2008 \| Source: AHA: Scientific Sessions 2008 Stem Cell Infusion After Primary PCI Fails to Improve LV Function By Debra Beck NEW ORLEANS—Intracoronary infusion of bone marrow derived or peripheral blood derived stem cells failed to improve several measures of myocardial and… Wednesday, November 12, 2008 \| Source: AHA: Scientific Sessions 2008 Intra-Individual Comparison Shows Less Late Loss With SES vs. PES By Debra Beck NEW ORLEANS—In the first intra individual comparison of drug eluting stents (DES), German investigators demonstrated that, within a single patient, coronary… Wednesday, November 12, 2008 \| Source: AHA: Scientific Sessions 2008 TIMACS: Early Invasive Strategy Improves Outcomes in NSTE ACS Patients By Debra Beck NEW ORLEANS—An early invasive strategy appears to improve refractory ischemia in high risk patients with non ST segment elevation acute coronary syndromes… Tuesday, November 11, 2008 \| Source: AHA: Scientific Sessions 2008 Clopidogrel Dose Tailored to Platelet Reactivity Reduces Early Stent Thrombosis By Debra Beck NEW ORLEANS—In patients undergoing non emergent percutaneous coronary intervention (PCI) who are poor responders to clopidogrel, adjusting the loading… Monday, November 10, 2008 \| Source: AHA: Scientific Sessions 2008 DES Safe in Diabetic Patients, Hints at MI and Mortality Benefit By Debra Beck NEW ORLEANS—In a propensity matched analysis of almost 3,000 diabetic patients, drug eluting stents (DES) were associated with decreased rates of death,… Wednesday, October 29, 2008 \| Source: TCT 2008 Prasugrel Improved Platelet Inhibition and Outcome By TCT Daily Staff First generation and second generation thienopyridines such as clopidogrel come with a number of limitations that are significantly ameliorated by the… Tuesday, October 28, 2008 \| Source: TCT 2008 DES in Unprotected Left Main Disease Safe at 4 Years By TCT Daily Staff Long term follow up data show that the use of drug eluting stents (DES) can be safe and effective in unprotected left main coronary artery disease (LMCA),… Tuesday, October 28, 2008 \| Source: TCT 2008 Pooled Meta-Analysis Shows DES Safe, Effective vs. BMS By TCT Daily Staff Findings from 2 analyses of pooled data from randomized controlled trials and large registries demonstrate that drug eluting stents (DES) are associated… Monday, October 27, 2008 \| Source: TCT 2008 Answers Needed About Treatment of Peripheral Arterial Disease By TCT Daily Staff In an interview during TCT 2008 in Washington, DC, Michael R. Jaff, DO, medical director of the Vascular Diagnostic Laboratory at the Massachusetts General… Monday, October 27, 2008 \| Source: TCT 2008 Right-to-Left Shunt in PFO Patients Often Posture-Dependent By TCT Daily Staf Up to 40% of cases of right to left shunt (RLS) in patients with patent foramen ovale (PFO) are posture dependent, according to research presented at… Friday, October 24, 2008 \| Source: TCT 2008 OCT Detects Vulnerable Plaque Better than Other Modalities By TCT Daily Staff Optical coherence tomography provides better contrast and resolution of arterial pathology than intravascular ultrasound and virtual histology, demonstrating… Friday, October 24, 2008 \| Source: TCT 2008 Olmesartan Promising for Plaque Regression in Stable Angina By TCT Daily Staff The angiotensin II receptor blocker olmesartan appears to foster coronary plaque regression in patients with stable angina, according to an abstract from… Thursday, October 23, 2008 \| Source: TCT 2008 Number of Off-label Indications Correlated With Risk of MACE After DES By TCT Daily Staff The risk of major adverse cardiac events increases in step wise fashion with each additional off label indication in patients implanted with drug eluting… Wednesday, October 22, 2008 Common Genetic Variation Linked to Risk of Restenosis By TCT Daily Staff A common polymorphism in a gene that plays an important role in regulating cell proliferation has been linked to restenosis after percutaneous coronary… Wednesday, October 22, 2008 \| Source: TCT 2008 Trimetazidine Minimizes Risk of Periprocedural MI By TCT Daily Staff Pretreatment with the metabolic agent trimetazidine for one week before percutaneous coronary intervention (PCI) can minimize the risk of myocardial reperfusion… Tuesday, October 21, 2008 Clopidogrel Resistance Linked to Increased Risk of Ischemic Events By TCT Daily Staff Resistance to clopidogrel is an independent predictor of long term cardiovascular events after drug eluting stent implantation in patients with stable… Tuesday, October 21, 2008 Triple-antiplatelet Therapy Demonstrates Superiority Over Dual Therapy By TCT Daily Staff Triple antiplatelet therapy with cilostazol appears to be superior to standard dual antiplatelet therapy in providing safe, long term protection against… Monday, October 20, 2008 Drug-coated Balloon Angioplasty Provides Long-Term Benefits By TCT Daily Staff Paclitaxel coated balloons appear to prevent restenosis and the need for repeat revascularization over a two year period, according to an abstract from… Monday, October 20, 2008 Everolimus-Eluting Stent Associated with Lower Complications at One Year By TCT Daily Staff Although both are considered effective, the Xience V everolimus eluting stent demonstrated lower complication rates one year post discharge compared with… Thursday, October 16, 2008 BBC ONE: In Bifurcation Stenting, Keep It Simple By Kiersten Feil Washington, DC—For unselected bifurcation lesions, a simple stenting strategy with drug eluting stents (DES) is superior to a complex strategy, according… Thursday, October 16, 2008 ISAR-TEST 2: “Dual DES” Similar to Cypher, Surpasses Endeavor By Caitlin Cox Washington, DC—Polymer free stents eluting both probucol and sirolimus, dubbed "Dual DES," achieve similar levels of restenosis and in stent late lumen… Thursday, October 16, 2008 SORT-OUT III: Higher TLR with Endeavor By TCT Daily Staff In early results from the SORT OUT III trial, patients with CAD implanted with an Endeavor zotarolimus eluting stent had significantly higher rates of… Wednesday, October 15, 2008 A Peek Behind the Guidelines Curtain By TCT Daily Staff Since joining forces 25 years ago to develop guidelines for the use of pacemakers, the American College of Cardiology and American Heart Association have… Wednesday, October 15, 2008 Absorb: Two-Year Follow-Up By TCT Daily Staff Patients treated with a bioabsorbable everolimus eluting stent had a low risk of major adverse cardiac events during two years of follow up, according… Wednesday, October 15, 2008 ARNO, NAPLES: Bivalirudin Lowered Bleeding in Elective PCI By TCT Daily Staff Results from two European studies presented on Wednesday indicate that bivalirudin reduced bleeding rates compared with heparin, even in elective PCI.… Wednesday, October 15, 2008 ASSIST: PCI with Eptifibatide in STEMI Did Not Improve Outcomes By TCT Daily Staff STEMI patients receiving heparin plus eptifibatide prior to primary PCI do not have improved outcomes compared with patients who receive heparin alone,… Wednesday, October 15, 2008 Carotid Angioplasty with Cutting Balloon Yields Low Complication Rates By TCT Daily Staff Mid term results from an observational study of cutting balloon angioplasty for fibrocalcific carotid artery lesions were encouraging, according to Shane… Wednesday, October 15, 2008 Cleveland Clinic Fellow Receives Young Investigator Award By TCT Daily Staff At the 20th anniversary of the TCT symposium Research Foundation presented Mehdi H. Shishehbor, DO, MPH, PhD, with the Thomas J. Linnemeier Spirit of… view all conference news